Hello Marc7 and welcome to the forums here at Malwarebytes.org Malwarebytes should not be run alone; it is designed to run along-side an anti-virus software. Malwarebytes is an anti-malware program, and while it does get some viruses, it is not an anti-virus program. As for SpyBot, if you have Malwarebytes, there is no need to have SpyBot as well. Unfortunately SpyBot is kind of a resource-heavy program and Malwarebytes basically gets everything that SpyBot gets and more. My personal recommendations for an antivirus is Microsoft Security Essentials for a free antivirus, and Kaspersky for a paid antivirus. Also, while Malwarebytes works well with most antivirus programs, it is adviseable to add exclusions for Mbam in the antivirus and for the antivirus in Mbam, to minimize any potential conflicts (which again, are uncommon but can happen). Tutorials for doing so may be found here. Please don't hesitate to post again should you have any further questions or concerns. Happy computing!