Downtown Computer

We have been installing the active running, start with Windows, setup of Malwarebytes. In the last 3 weeks or so, computers have been freezing/locking up. This has been occuring with both Vipre antiviral and Avast antiviral. Our customers like the active running, active protection, start with Windows options. What can we do to prevent this freeze up and still maintain active protection, load with Windows? We like malwarebytes. Please help.