This is a strange one. I've been playing Monster Hunter World with Malwarebytes installed for a month now and the game ran just fine until today. Trying to startup the game just loads a black screen and the game just hangs there. After a lot of searching, file management, and troubleshooting, I found that disabling Malware and PUP protection "fixes" it and now the game runs just fine. I tried adding the game to the Allow List, folder AND .exe, but the game will just not load if Malware and PUP protection is enabled.
