I also had this problem after my Malwarebytes premium upgraded itself to the 3.0.6.1469, package version 1.0.50, Update package version 1.0.1153.....current iteration. Curiously (after the upgrade) my Kapersky virus scan identified a potentially unwanted Adware bot identified as SyncTask.exe. (Not saying the upgrade was related to the acquisition of the bot.) Kaspersky could not quarantine this file and suggested that it be deleted. I let it do so and after a couple of reboots and rescans (with the Kaspersky) I was abel to enable the Real time Web protection feature of Malwarebytes. Don't know if this may be your problem but it seemed to be mine. (Windows 10 running on a Sony Vaio w/Intel core i3 processor).