DerekL

Thank you for your suggestion @dcollins. In the DeepGuard Monitored Applications list, Malwarebytes does not appear (with DeepGuard switched on), so cannot change the application permission to allow it.

I have updated from Malwarebytes Premium 2.? to 3.0.5 today and am also now getting the "Unable to connect to service" error I have Windows 10 Home 64 bit installed and also use TalkTalk Supersafe 16.5 (F-Secure) TalkTalk SuperSafe 16.5 Computer Security 14.176 build 101 DeepGuard 5.0 build 593 E-mail Filtering 1.02 build 22223 Management Agent 8.30 build 43258 User Interface 19.10 build 270 Virus Protection 11.00 build 22424 Through trial and error spending quite a few hours to identify the problem, I have found that switching off the DeepGuard feature in TalkTalk Supersafe 16.5 (F-Secure) allows me to connect to the service everytime. Switching it back on again it reverts to the "Unable to connect to service" error. Switching off the Virus Protection feature has no affect on the connection.