[Updating program -- Please, stop making it "mandatory"]

On 8/26/2015 at 7:12 PM, DeGraff said:

If you select this setting, MalwareBytes will still ignore it from time to time.  To get rid of the annoying popup (several times a day), 1) make sure "Check for program updates..." is checked, 2) go to "Advanced Settings" and turn off "Enable self-protection early start" and then turn off "Enable self-protection module", 3) go to "C:\ProgramData\Malwarebytes\Malwarebytes Anti-Malware" and delete "mbam-setup.exe" (what triggers the popups), 4) go back to "Advanced Settings" and turn back on "Enable self-protection module" and "Enable self-protection early start" if you wish those protections (I recommend them), and enjoy no more nags for a while until the software chooses to ignore the setting again.  As for why I choose to update on my schedule, MalwareBytes ruined my Christmas / New Year's vacation by releasing a fatal update to all of my clients' computers on 2012/12/27 (verison 1.70.1.1100) which rendered all of their computers unable to boot up.  Also, the current version (2.1.8.1057 2015/06/29) does not work on many computers (massive crippling delays causing boot times to exceed an hour or not boot at all except Safe Mode) requiring them to continue using 2.1.6.1022 2015/04/21.  These reasons are why I always update security software manually after testing the updates on unimportant computers in my lab.  I always keep definitions updating constantly (exclusively use the Pro edition) and add an update for 5 minutes after boot to the schedule.

I made an account just to thank you for this answer! This is the solution that I was looking for. I assume you mean to un-check the "Check for program updates..." setting. This post is the Best Answer/Solution in my opinion.

On a side note, all of these comments about MB definitions needing to be updated to protect you from zero-days is BOGUS. Nothing that uses definitions to check for malware can reliably stop a true zero-day attack, because a zero-day is something that by definition has not been seen before! A heuristic scan would have a better chance of detecting something like that, but heuristic detection shouldn't need updated malware signatures to operate, so the people who keep saying that updating definitions will protect you against zero-days seem to just be spreading misinformation.