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Microsoft Excel & Word Problem

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Hello just to let you know that this morning I couldn't start Microsoft Excel or Word 2013. It gave an error message:

The operating system is not presently configured to run this application.

when I disabled Malwarebytes anti-malware I could open the program as normal. 

It might just be me or it might be an update that you've done very recently that is broken other people's Excel and Word. I'm running windows 10 1803 OS build 17134.407

Malwarebytes version is an image attached.



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  • 2 weeks later...

Hello @RussD

It looks like this might not be an Anti-Exploit issue. 
Something's up with the system configuration.Could be from a recent Windows update too. 

Refer this https://www.kapilarya.com/the-operating-system-is-not-presently-configured-to-run-this-application

Can you download the mb-support tool from https://downloads.malwarebytes.com/file/mbst.

Run the tool/ Go to Advanced options and run Clean. This will cleanup your existing Malwarebytes product and will perform a clean install.

Can you please let us know if you continue to experience the same issue after a clean reinstall of MB3 ?

Thank you.

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Just FYI, until this issue is resolved, rather than disabling Exploit Protection completely you can just disable protection for those specific MS Office applications which are affected by following the instructions found in this post.  Other users with this issue have already confirmed that this works and it will allow you to keep Exploit Protection active for all of your other applications which is especially important for your web browsers; the most frequently targeted applications by malicious exploits.

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  • 3 months later...

I had this problem with Microsoft Excel, every time I tried to open an Excel file or launch the Excel application I got the error "operating system is not configured to run this application".  I finally managed to figure out that it was my antivirus, Bitdefender.  Bitdefender's "Advanced Threat Defense" that was causing the problem. I SOLVED the problem by adding the Excel executable file (i.e., EXCEL.EXE) to the Bitdefender's "Protection<Advanced Threat Defense<Settings" as an "Excepted Application".  Now Excel launches with no problems.  Hope this helps!

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