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Greetings,

They'll probably leave the automatic USB scanning to the AVs as not to create conflicts and the same goes for emails.  That said, if any malware tries to execute from a USB drive or an email, including not only email attachments, but also embedded links and documents, the various layers in Malwarebytes Premium will detect them and stop them before they are able to infect the system.

As for Windows Defender, it's left on by default deliberately for the sake of compatibility as not all users wish to use Malwarebytes alone, but you can usually rectify this easily if you do want Malwarebytes running on its own and Windows Defender disabled by changing the setting in Malwarebytes under Settings>Application below Windows Action Center to Always register Malwarebytes in the Windows Action Center.  That will register Malwarebytes as your chosen active AV protection and Windows Defender should automatically be turned off by Windows.

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