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Malwarebytes Working With Windows 10 Defender

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I'm confused as to how Malwarebytes should work/interact with Windows 10 Defender.  I have MB installed and have listed several application/files/folders as exclusions.  Should I  duplicate these same exclusions in Windows Defender?  Seems redundant if I do, but what's the risk if I don't?  Additionally, are there any Windows Security (or other) settings which should be enabled/disabled to facilitate an optimal coexistence between MB and  Defender?  Thanks in advance for your help.

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 Ok.  Thanks vbarytskyy.  That makes sense.

Now, what about any other applications/files/folders I may wish to exclude?   Should I exclude them in BOTH Malwarebytes and Defender or just in Malwarebytes, and why?

Next, are there any other Malwarebytes-suggested Windows 10 settings?  If no other Malwarebytes-suggested Windows settings, please tell me.

Thanks again.

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