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What is the reaction of resident shield of AV for obfuscated file?

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So, if I have malicious file in my computer, scanning of file system (or something like that) tagged that file as a danger. If I obfuscated this malicious file (e.g. with NOP instructions or adding JMP instructions), then scanning of file system not tag that it is a dangerous file. But if after run this file is into memory, what is reaction resident shield of antivirus on this file? Obfuscated file is running in memory, is it tagged by resident shield or what? Excuse my english. Can somebody help me? PLEASE

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