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Windows 10 Professional, 64-bits with Malwarebytes 188.8.131.523, running on a system with i5-330P CPU, 16 GBs memory and Samsung EVO SSD. The system also has Vipre Antivirus version 184.108.40.206. The system runs just fine, no issues with Malwarebytes except performance. If and when Malwarebytes protection enabled, MS Office applications, such as Word and Excel, have a substantial delay staring up. I've measured the the time it takes to start up with PassMark AppTimer V1.0 build 1010. With Malwarebytes active, this is the time it showed: C:\Program Files\Microsoft Office\Office15\WINWORD.EXE 0.9636 That's one second that gets even a lot worse, if and when the word document is opened from a network share. Subsequent opening a different word document has no delays, as long as the first document is open. If it's closed, the delay is there. Stopping and disabling the "Malwarebytes Service" in services and re-running the test shows this: C:\Program Files\Microsoft Office\Office15\WINWORD.EXE 0.1556 That's about six times faster, than the previous test and opening up word document from network share is just as fast. Excel shows the same delay at startup, if Malwarebytes enabled. I've just built a system with an i5-8400 CPU, 16 Gbs memory and Samsung NVMe EVO drive with Windows 10 Professional, 64-bits. Adding Malwarebytes slowed the MS applications the same way on this system too. Both systems have licensed installation, as shown in the attached image. Question... Is there a reason why MS Office apps are slowed down with Malwarebytes, at times to a crawl? Windows 10 has a number of built-in memory protections for apps. Could the some of the Malwarebytes memory protection, in "Advance Settings\Advanced Memory Protection" causing the conflict that slows the apps start up time down? TIA... PS: Internet Explorer 11 has an even worse start up time with Malwarebytes...