I use whatever works, Malwarebytes works. I also use combofix for rootkits, between the two they get just about everything, although combofix does have a somewhat alarming tendency to false alarm In the old days Spybot & Adaware were good, now Spybot's immunise & Spywareblaster are simply for an added level of protection for those who tend to be infected easily even if it does slow down their browsing experience. The separation of Virus detection and spyware detection by some major products in the enterprise is totally wrong & I for one cannot understand why the company where I work sticks with McAfee for example.