Windows 10 here.
I've had the same problem with Kaspersky Total Security 2020 and Malwarebytes 3 and now 4.
I've tried the suggestions here - but I still have to disable realtime Ransomware Protection and Exploit Protection.
I can live with this, as I've had a complete PIA week - I couldn't load Firefox, Thunderbird or iTunes or the setup screen for the icloud client. Also some problems updating Freefile sync.
Everything is fine without Kaspersky or without Malwarebytes, or with both running and just those two settings disabled in Malwarebytes.
I've had enough tinkering rebooting, hanging, hourglasses etc - I'll live like this
(and will keep an eye on this thread)