Installed Win10 Fall Creators 1709 this morning, and the exact same issue started. Running version 188.8.131.523 (same as prior to Creators update). Now, IE 11 will only open if I Run as Administrator. If I turn off Internet Explorer in Managed Protected Applications, IE opens normally. I don't use IE 11 as my default browser, but unfortunately Outlook defaults to IE 11 when you use View in Browser for an email - so I need to keep IE 11 around for those instances. Turned off IE as a protected app for now.