I've got a client who requires the use of Pulse Secure's Secure Application Manager to connect to their network. https://docs.pulsesecure.net/WebHelp/Content/PCS/PCS_AdminGuide_8.2/CHAPTER 24 Secure Application.htm
I've been using the VPN software for years but Malwarebytes 3 interferes with VPN traffic. For example, when I try to connect to SQL Server using Management Studio on my PC the first login will eventually fail with "network name not found". If I click OK within about a minute of the error message to log in again then it will succeed. More than that causes it to fail again. Any task in Management Studio that requires a new connection process shows the same fail -> immediately retry -> success behaviour. For example, all queries run in the same tab window will run fine no matter how long between query executions. Opening a new tab window (which requires a new connection) fails and then succeeds when retrying. The same sort of behaviour can be seen when trying to remote desktop into a server using Remote Desktop Connection.
Shutting down Malwarebytes makes all the problems go away. This issue exists on Windows 8.1 and Windows 10 (upgraded my PC, uninstalled and reinstalled Malwarebytes but that didn't fix the issue).