Hello folks. Just wanted to provide a status update of my personal experience in dealing with this issue.
We initially tried to disable SCEP's real time scanning. After doing this, we continued to experience issues.
We then disabled Anti-Exploit across the board, still issues for a handful of users
After hours of pouring over event logs, appcrash logs and reviewing end-users pcs. I noticed that there was a product called "Microsoft Antimalware" installed. I have no idea how it got there, but it was using similar file / service names (msmpsvc) to SCEP / Microsoft Security Essentials.
What a complete waste of time I made for myself by overlooking it.
This morning I created a simple SCCM package for uninstalling this product.
msiexec.exe -parameters "/x '{0c243024-b7af-478b-b6f1-574a4ab0e07c}' REBOOT=ReallySuppress /q"
I am crossing my fingers that this finally puts this issue to rest, and that I never have to think about this or anything ever again.
Side note, does anyone know if this affects both the 1.80.1.1011 and 1.80.2.1012 versions of Malware Bytes Enterprise?