I have been having this problem from before upgrading from Win 8.1 Pro 64 bit to Win 10 Pro 64 bit. I'm not sure what is failing when it happens, because the screen will still be there, but I am unable to get into task manager or anything else to diagnose. Strangely, the mouse moves around, but won't actually activate anything. I end up shutting the computer down to restart. The reason I'm "blaming" malwarebytes real-time protection, is that when I turn it off, the computer runs for days without the problem. That is the ONLY difference. I have already performed the mbam-clean procedure and reinstalled. It has already frozen again. I would really like to have real-time protection again. FYI, the "self-protection" checkbox is not checked as per the recommended settings. Is there anything I can provide in the way of logs or whatever to help you diagnose what's happening? Thanks in advance!